70590-62-4Relevant articles and documents
Synthesis of aminoderivatives of 4,5,6,7-tetrahydro-benzothiazole. I. 4,5,6- and 7-amino and N-methyl amino derivatives with central dopaminergic activity
Maillard,Delaunay,Langlois,et al.
, p. 451 - 456 (2007/10/02)
4-Oxo and 6-oxo-4,5,6,7-tetrahydro-benzothiazoles were prepared from diester derivatives of thiazole through Dieckmann cyclisation. The 7-oxo compound was synthesized by formation of a thiazole ring on 2-bromo-1,3-cyclohexanedione. The ketones were tranformed into amines and N-methylamines by reductive amination. The 5-amino derivatives were obtained by Hofmann reaction of the corresponding amides. The amines and N-methylamines in the 6-position have central dopaminergic properties. Their isomers in the 4, 5 or 7 positions are inactive.
New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications
-
, (2008/06/13)
This invention relates to compounds having the general formula: STR1 and their pharmaceutically acceptable acid addition salts having the formula: STR2 in which: R represents hydrogen or a C1-4 alkyl radical, R' represents hydrogen or a C1-4 alkyl radical, m is 0, 1, 2 or 3, n is 3, 2, 1 or 0, the sum m+n being always equal to 3, and X- represents an anion formed by a pharmaceutically acceptable acid. Said compounds are typically useful as analgesic agents and as stimulants of the sympathetic nervous system, and also as central and peripheral vasoregulator agents.
