705961-96-2 Usage
Uses
Used in Pharmaceutical Industry:
5-(2-Fluorophenyl)nicotinic acid is used as a potent and selective agonist for the G-protein-coupled receptor GPR109A. It plays a crucial role in mediating the anti-inflammatory and lipid-lowering effects of niacin, which are beneficial in the treatment of cardiovascular diseases and metabolic disorders.
Used in Cardiovascular Disease Treatment:
5-(2-Fluorophenyl)nicotinic acid is used as a therapeutic agent for cardiovascular diseases. Its agonistic action on the GPR109A receptor helps in reducing inflammation and lowering lipid levels, which are key factors in the development and progression of cardiovascular conditions.
Used in Metabolic Disorder Treatment:
5-(2-Fluorophenyl)nicotinic acid is used as a treatment for metabolic disorders, such as dyslipidemia and insulin resistance. Its ability to modulate the activity of GPR109A receptor contributes to the regulation of lipid metabolism and glucose homeostasis, thereby improving overall metabolic health.
Used in Drug Development:
5-(2-Fluorophenyl)nicotinic acid is used as a lead compound in the development of new drugs targeting the GPR109A receptor. Its structure and properties provide valuable insights into the pharmacological and physiological functions of this receptor, facilitating the design and synthesis of novel therapeutic agents with improved efficacy and safety profiles.
Used in Research:
5-(2-Fluorophenyl)nicotinic acid is used as a research tool for studying the pharmacological and physiological functions of the GPR109A receptor. Its selective agonistic activity allows researchers to investigate the receptor's role in various biological processes, such as inflammation, lipid metabolism, and glucose homeostasis, and to explore its potential as a therapeutic target for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 705961-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,5,9,6 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 705961-96:
(8*7)+(7*0)+(6*5)+(5*9)+(4*6)+(3*1)+(2*9)+(1*6)=182
182 % 10 = 2
So 705961-96-2 is a valid CAS Registry Number.
705961-96-2Relevant academic research and scientific papers
Li, Xin,Abell, Chris,Congreve, Miles S.,Warrington, Brian H.,Ladlow, Mark
, p. 989 - 998 (2004)
A new phase-tag 1 which facilitates the parallel solution phase synthesis of carboxylic acids, esters, and carboxamides is reported. The new phase tag assists compound purification by enabling the selective resin capture of reaction products in either a reversible pH dependent manner (solid-phase extraction), or irreversibly in a Diels-Alder reaction.
