70615-49-5

Upstream product

• 772-38-3 4-tert-Butylphenylacetylene 
• 135883-30-6 1-(4-tert-butylphenyl)-2-trimethylsilylethyne 

Downstream Products

• 1551099-81-0 C₁₈H₁₈Cl₂O₂S 
• 1551101-91-7 C₁₈H₁₈Cl₂O₂S 
• 21886-62-4 2-chloro-1-[4-(1,1-dimethylethyl)phenyl]ethanone 
• 1313869-30-5 (Z)-2-chloro-1-(4-tert-butylphenyl)penta-1,4-dienyl acetate 

Relevant academic research and scientific papers

Transition-Metal-Free One-Step Synthesis of Ynamides

A robust transition-metal-free one-step strategy for the synthesis of ynamides from sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides is presented. This method is not only effective for internal ynamides but also amenable for terminal ynamides. Various functional groups, even the vinyl moiety, are compatible, and thus, this strategy offers the opportunity for further functionalization.

Gold-Catalyzed Highly Chemo- and Regioselective C-H Bond Functionalization of Phenols with Haloalkynes

A highly chemo- and stereoselective addition of unprotected phenols to haloalkynes was developed. A ligand and counterion controlled process enabled the highly site-selective and chemoselective C-H bond functionalization of phenol derivatives with haloalkynes in moderate to excellent yield at room temperature. The simple availability of the starting materials in combination with the preferred para-C-H functionalization over a competing O-H insertion makes this an attractive protocol. The stereoselectivity of the products depends on the choice of the catalyst. From a synthetic prospective, this method offers an efficient route towards vinyl chlorides, which are valuable precursors for the synthesis of pharmaceutical drugs.

Synthesis of 1-chloroalkynes from alkynylsilanes using trichloroisocyanuric acid as chlorinating agent

A new method is reported for preparing 1-chloroalkynes from alkynylsilanes using trichloroisocyanuric acid (TCCA) as chlorinating agent and AgNO 3 for in situ desilylation. The method is selective for trimethylsilyl-protected alkynes relative t