70618-31-4

Usage

Chemical structure

Composed of a pyridin-2-ylethanone group and a 4-methoxyphenyl group, both attached to the thiosemicarbazone moiety.

Potential anti-cancer properties

Demonstrated ability to inhibit cancer cell growth by inducing apoptosis and inhibiting angiogenesis.

Chemosensitizer potential

Investigated for its ability to enhance the efficacy of chemotherapy drugs.

Unique structure

The combination of the pyridin-2-ylethanone and 4-methoxyphenyl groups attached to the thiosemicarbazone moiety contributes to its promising biological activities.

Subject of interest

The compound's structure and biological activities make it a focus for further research and potential therapeutic applications in oncology.

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 1122-62-9 2-acetylpyridine 
• 13278-67-6 4-(4-methylphenyl)-3-thiosemicarbazide 

Relevant academic research and scientific papers

A thiourea structure unit including shrinking amino aromatic compound and its preparation method and application (by machine translation)

The invention relates to the technical field of pharmaceutical chemistry, and in particular relates to a thiourea structure unit including shrinking amino aromatic compound and its preparation method and application. The present invention provides including shrinking amino thiourea structure unit of the aromatic heterocyclic compound with the gastric cancer cells through the inner metal ion chelating form stable complexes, thereby suppressing the MGC803 gastric cancer cell proliferation activity. The results of the embodiment of the display, and the compound 3 - AP compared with, the present invention provides including shrinking amino thiourea structure unit of the aromatic heterocyclic compound to stomach MGC803 has better proliferation inhibitory activity. (by machine translation)

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

There is a constant need for new therapies against multidrug resistant (MDR) cancer. An attractive strategy is to develop chelators that display significant antitumor activity in multidrug resistant cancer cell lines overexpressing the drug efflux pump P-glycoprotein. In this study we used a panel of sensitive and MDR cancer cell lines to evaluate the toxicity of picolinylidene and salicylidene thiosemicarbazone, arylhydrazone, as well as picolinylidene and salicylidene hydrazino-benzothiazole derivatives. Our results confirm the collateral sensitivity of MDR cells to isatin-β-thiosemicarbazones, and identify several chelator scaffolds with a potential to overcome multidrug resistance. Analysis of structure-activity-relationships within the investigated compound library indicates that NNS and NNN donor chelators show superior toxicity as compared to ONS derivatives regardless of the resistance status of the cells.

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.