70625-05-7

Upstream product

• 70625-03-5 3-benzyl-2-(α-hydroxyethyl)-4-methylthiazolium tetrafluoroborate 

Downstream Products

• 1188410-56-1 3-benzyl-4-methyl-2-(3,4-dichlorophenyl)selenocarbamoylthiazolium inner salt 
• 1188410-57-2 3-benzyl-4-methyl-2-(4-trifluoromethylphenyl)selenocarbamoylthiazolium inner salt 
• 1188410-55-0 3-benzyl-4-methyl-2-(4-chlorophenyl)selenocarbamoylthiazolium inner salt 
• 1188410-54-9 3-benzyl-4-methyl-2-phenylselenocarbamoylthiazolium inner salt 

Relevant academic research and scientific papers

The [3 + 2] cycloaddition reaction of thiazole carbene-derived C-C-Se 1,3-dipoles: A concise and highly efficient strategy for the construction of multifunctional dihydroselenophenes and selenopheno[2,3-b]pyrazines

The first study on the reaction of C+-C-Se- 1,3-dipoles with electron-deficient alkenes and alkyne is reported. 2-Arylselenocarbamoylthiazolium inner salts, the unique thiazole carbene-derived C+-C-Se- 1,3-dipol

α-Keto Acid Dehydrogenases: A Chemical Model

A model system for the involvement of lipoic acid in α-keto acid dehydrogenase systems is described. 2-(α-Hydroxyethyl)-3-benzyl-4-methylthiazolium tetrafluoroborate (6) serves as precursor for an analogue of the thiamine-bound active aldehyde 1 in the natural system.The model active aldehyde 7 reacts with linear disulfides, yielding thiols and thioesters.The 1,2-dithiolane, methyl lipoate (14), is unreactive under model reaction conditions.The tetrahedral intermediate which would be formed from methyl lipoate (14) plus an active aldehyde analogue 19 has been generated in a nonbiomimetic fashion.The synthetic tetrahedral intermediate 17 undergoes the reverse of the biological, disulfide reductive cleavage reaction.