70625-28-4Relevant academic research and scientific papers
Metabolic analysis of the cinnamate/monolignol pathway in Carthamus tinctorius seeds by a stable-isotope-dilution method
Sakakibara, Norikazu,Nakatsubo, Tomoyuki,Suzuki, Shiro,Shibata, Daisuke,Shimada, Mikio,Umezawa, Toshiaki
, p. 802 - 815 (2008/03/27)
The present study established a system for comprehensive metabolic analysis of the cinnamate/monolignol and lignan pathways by the use of a stable-isotope-dilution method. The system was successfully applied to characterization of the pathways in Carthamu
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers
Shoeib, Nagwa A.,Bibby, Michael C.,Blunden, Gerald,Linley, Peter A.,Swaine, David J.,Wheelhouse, Richard T.,Wright, Colin W.
, p. 1445 - 1449 (2007/10/03)
Bioassay-guided fractionation was applied to the cytotoxic chloroform fraction of the red alga Polysiphonia lanosa. The major compounds of the most active fraction were identified using GLC-MS analysis as lanosol (1), methyl, ethyl, and n-propyl ethers of lanosol (1a, 1b, and 1c, respectively), and aldehyde of lanosol (2), although 1b appears to be an artifact arising during the fractionation procedure. These compounds and other known bromophenols were synthesized in addition to four novel isomers (3, 3a-c). The cytotoxic activities of all the synthetic compounds were determined against DLD-1 cells using the MTT assay. Compounds with IC50 50 = 1.72 and 0.80 μmol, respectively), and its effect on the cell cycle was studied using flow cytometry.
