70626-62-9Relevant academic research and scientific papers
Dipeptide-catalyzed asymmetric aldol condensation of acetone with (N-alkylated) isatins
Luppi, Gianluigi,Cozzi, Pier Giorgio,Monari, Magda,Kaptein, Bernard,Broxterman, Quirinus B.,Tomasini, Claudia
, p. 7418 - 7421 (2007/10/03)
The aldol condensation of acetone with several isatins is described. The desired compound was obtained in quantitative yield and with good enantioselectivities up to 77%. The best results were obtained with 10 mol % H-D-Pro-L-β3-hPhg-OBn as a c
Solution-phase automated synthesis of tripeptide derivatives
Kuroda,Hattori,Kitada,Sugawara
, p. 1138 - 1146 (2007/10/03)
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.
