70654-85-2

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DIOXO-1,3-DIHYDROBENZO[C]THIOPHENE-5YL AMINE is used as a key intermediate in the synthesis of various drugs for its unique structure and biological activity.
Used in Organic Synthesis:
2,2-DIOXO-1,3-DIHYDROBENZO[C]THIOPHENE-5YL AMINE is used as a building block in the development of novel compounds with pharmacological properties, contributing to the advancement of organic synthesis techniques.
Used in Medicinal Chemistry:
2,2-DIOXO-1,3-DIHYDROBENZO[C]THIOPHENE-5YL AMINE is employed as a starting material for the design and synthesis of new therapeutic agents, leveraging its potential in the field of medicinal chemistry.

InChI:InChI=1/C8H9NO2S/c9-8-2-1-6-4-12(10,11)5-7(6)3-8/h1-3H,4-5,9H2

Upstream product

• 174751-95-2 5-nitro-1,3-dihydrobenzo[c]thiophene 2,2-dioxide 
• 2471-92-3 1,3-Dihydrobenzothiophen 
• 2471-91-2 1,3-dihydrobenzo[c]thiophene-2,2-dioxide 
• 91-13-4 α,α'-dibromo-o-xylene 
• 99-51-4 4-nitro-o-xylene 
• 6425-66-7 1,2-bis-bromomethyl-4-nitro-benzene 
• 95-47-6 o-xylene 

Downstream Products

• 1126430-45-2 N-(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)-4-{2-(ethylamino)-4-[3-methyl-5-(methyloxy)phenyl]-1,3-thiazol-5-yl}-2-pyrimidinamine 

Relevant academic research and scientific papers

Reactions of 1,3-dihydrobenzo[c]thiophene 2,2-dioxides with electrophilic agents

Nitration, sulfonation, and iodination of 1,3-dihydrobenzo[c]thiophene 2,2-dioxide and its derivatives with electron-releasing and electron-withdrawing substituents were studied. Electrophilic substitution in 1,3-dihydrobenzo[c] thiophene 2,2-dioxide occurs at position 5. The presence of electron-withdrawing substituents in this position hinders further substitution, while electron-releasing substituents in positions 5 and 6 direct an electrophile to position 4.

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Benzosulfones as photochemically activated sulfur dioxide (SO2) donors

Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic agent. However, due to its gaseous nature, localizing SO2 generation is challenging. Herein, various 1,3-dihydrobenzo[c]thiophene 2,2-dioxides (benzosulfones) were prepared as candidates for photochemically activated sulfur dioxide (SO2) generation. These compounds were found to be stable in buffer but were photolysed upon irradiation with UV light to generate SO2. Our data indicates that photolysis of benzosulfones depends on substituents, and that the presence of electron donating groups results in an enhanced yield of SO2. This journal is