7066-25-3 Usage
Uses
Used in Pharmaceutical Development:
Benzo[f]quinazolin-1(2H)-one, 3-aminois utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and potential bioactivity make it a valuable candidate for the development of new drugs with therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Benzo[f]quinazolin-1(2H)-one, 3-aminoserves as a promising scaffold for the design and synthesis of novel compounds with potential therapeutic effects. Its structural features allow for modifications and functionalization to optimize pharmacological properties.
Used in Biologically Active Substances:
Due to its potential pharmacological importance, Benzo[f]quinazolin-1(2H)-one, 3-aminois also used in the creation of biologically active substances. These substances may have applications in various areas of medicine, including the treatment of diseases and the enhancement of human health.
Check Digit Verification of cas no
The CAS Registry Mumber 7066-25-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,6 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7066-25:
(6*7)+(5*0)+(4*6)+(3*6)+(2*2)+(1*5)=93
93 % 10 = 3
So 7066-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H9N3O/c13-12-14-9-6-5-7-3-1-2-4-8(7)10(9)11(16)15-12/h1-6H,(H3,13,14,15,16)
7066-25-3Relevant academic research and scientific papers
Benzoquinazoline inhibitors of thymidylate synthase: Enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin- 1(2H)-ones
Pendergast,Johnson,Dickerson,Dev,Duch,Ferone,Hall,Humphreys,Kelly,Wilson
, p. 2279 - 2291 (2007/10/02)
The synthesis and thymidylate synthase (TS) inhibitory activity of a series of simple benzo[f]-quinazolin-1(2H)-ones are described. Fully aromatic 3-amino compounds with compact lipophilic substituents in the 9-position were found to have I50 values as low as 20 nM on the isolated enzyme, and represent the first examples of potent, folate-based TS inhibitors that completely lack any structural feature corresponding to the (p- aminobenzoyl)glutamate moiety of the cofactor. A number of the compounds also showed moderate growth inhibitory activity against a human colon adenocarcinoma cell line (SW480), with IC50 values as low as 2 μM.
