70661-09-5Relevant articles and documents
Some New Aspects on the Chemistry of 1,4-Benzoxazines
Chioccara, Francesco,Novellino, Ettore
, p. 1021 - 1024 (2007/10/02)
3-Methyl (3a) and 3-t-butyl-1,4-2H-benzoxazine (3b) were synthesized by cyclization of the appropriate acetamidoketone (Scheme 1).The former is a highly unstable molecule which rapidly converts in an intractable mixture, while the latter slowly undergoes aerial oxidation affording the hemiacetal 4.The 4H-forms of the same 3-methyl (6a) and of the parent 1,4-benzoxazine (9) could be obtained as 4-acetyl derivatives.This latter, by hydrolysis, gave the cyclic trimer 10.