70663-55-7Relevant academic research and scientific papers
Mechanistic Investigation of Phenylalanine Ammonia Lyase by Using N-Methylated Phenylalanines
Viergutz, Sandra,Poppe, Laszlo,Tomin, Anna,Retey, Janos
, p. 3601 - 3612 (2007/10/03)
N-Methyl-L-phenylalanine (5), N-methyl-4-nitro-L-phenylalanine (6), and N,N-dimethyl-4-nitro-L-phenyl-alanine (7·H+) were investigated as substrates of inhibitors of phenylalanine ammonia lyase from Petroselinum crispum. Whereas the former was
Synthesis, opiate receptor binding and analgesic activity of enkephalin analogues
Pless,Bauer,Cardinaux,et al.
, p. 398 - 411 (2007/10/16)
The synthesis and biological testing of analogues of Met-enkephalin, a recently discovered opioid peptide from mammalian brain, are described. Testing involved determination of affinity constants for an opiate receptor site and of analgesic potency in the tail-flick test in mouse. The effects on opioid activity on modifying various parts of the enkephalin molecule are discussed. Tyr-D-Ala-Gly-MePhe-Met(O)-ol1) (FK 33-824), which was highly active in these tests, was subsequently selected for clinical testing. The use of two complementary models - in vitro binding studies and in vivo test for analgesia - for the assessment of biological activity in the evaluation of analogues is explained.
