70677-62-2Relevant academic research and scientific papers
Development of chiral phosphoric acids based on ferrocene-bridged paracyclophane frameworks
Stemper, Jeremy,Isaac, Kevin,Pastor, Julien,Frison, Gilles,Retailleau, Pascal,Voituriez, Arnaud,Betzer, Jean-Francois,Marinetti, Angela
, p. 3613 - 3624 (2013)
This work deals with the development of a new family of planar chiral phosphoric acids based on a ferrocenophane/paracyclophane scaffold. The synthetic approach has been improved by taking advantage of a chiral phosphorylating agent to access enantiomerically enriched acids via diastereomers separation. These phosphoric acids have been used as catalysts for the enantioselective H-transfer reduction of α-substituted quinolines with Hantzsch esters. Optimization of both the catalyst and the Hantzsch reductant allowed ee values in the range 82-92% to be attained starting from α-arylquinolines. Copyright
