706785-16-2Relevant academic research and scientific papers
Bergman cycloaromatization of imidazole-fused enediynes: The remarkable effect of N-aryl substitution
Zhao, Zhengrong,Peng, Yunshan,Dalley, N. Kent,Cannon, John F.,Peterson, Matt A.
, p. 3621 - 3624 (2007/10/03)
A series of N-aryl substituted 'imidazole-fused' (Z) 3-ene-1,5-diynes was prepared and kinetic parameters for their Bergman cycloaromatization reactivities were determined. N-Arylation enhanced rates relative to N-alkyl derivatives by up to sevenfold (ANOVA p0.0001). The greatest enhancement was exhibited by the N-phenyl derivative (sevenfold at 145°C).
