706795-10-0

Basic information

• Product Name: C₂₀H₂₈N₂O₂
• CAS NO: 706795-10-0
• Molecular Weight: 328.455
• Mol File: 706795-10-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₈N₂O₂(706795-10-0)
• EPA Substance Registry System: C₂₀H₂₈N₂O₂(706795-10-0)

Safety Data

• Hazardous Substances Data: 706795-10-0(Hazardous Substances Data)

Upstream product

• 109138-28-5 1-(3-methoxyphenyl)-1-methylethylamine 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 149451-80-9 (2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol 
• 103127-52-2 ((S)-1-benzylallyl)carbamic acid tert-butyl ester 

Downstream Products

• 1539276-48-6 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-piperidin-1-yl-N'-propylisophthalamide 
• 1539276-52-2 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-N',N'-dipropyl-5-pyrrolidin-1-ylisophthalamide 
• 1539276-53-3 biphenyl-3,5-dicarboxylic acid 5-({(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}amide) 3-dipropylamide 
• 1539276-51-1 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]-propyl}-5-cyclohexyl-N',N'-dipropylisophthalamide 
• 1539276-38-4 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-piperidin-1-yl-N',N'-dipropylisophthalamide 
• 706803-45-4 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide 
• 1539276-50-0 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-piperidin-1-ylisophthalamide 
• 1539276-49-7 N-{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-3-piperidin-1-yl-5-(pyrrolidine-1-carbonyl)benzamide 

Relevant articles and documents

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit

Antimalarial hit 1SR (TCMDC-134674) identified in a GlaxoSmithKline cell based screening campaign was evaluated for inhibitory activity against the digestive vacuole plasmepsins (Plm I, II, and IV). It was found to be a potent Plm IV inhibitor with no selectivity over Cathepsin D. A cocrystal structure of 1SR bound to Plm II was solved, providing structural insight for the design of more potent and selective analogues. Structure-guided optimization led to the identification of structurally simplified analogues 17 and 18 as low nanomolar inhibitors of both, plasmepsin Plm IV activity and P. falciparum growth in erythrocytes.