70681-16-2Relevant academic research and scientific papers
Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity
Deigin, Vladislav,Ksenofontova, Olga,Khrushchev, Alexey,Yatskin, Oleg,Goryacheva, Alexandra,Ivanov, Vadim
supporting information, p. 1974 - 1977 (2016/10/22)
A novel chemical platform based on branched piperazine-2,5-dione derivatives (2,5-diketopiperazines) for creating orally available biologically active peptidomimetics has been developed. The platform includes a diketopiperazine scaffold with “built-in” fu
Cyclic dipeptides exhibit potency for scavenging radicals
Furukawa, Tadashi,Akutagawa, Takashi,Funatani, Hitomi,Uchida, Toshikazu,Hotta, Yoshihiro,Niwa, Masatake,Takaya, Yoshiaki
experimental part, p. 2002 - 2009 (2012/05/04)
Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against .OH and O2·- was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against .OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O2·-.
