706813-07-2Relevant academic research and scientific papers
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists
Shen, Dong-Ming,Zhang, Fengqi,Brady, Edward J.,Candelore, Mari Rios,Dallas-Yang, Qing,Ding, Victor D.-H.,Dragovic, Jasminka,Feeney, William P.,Jiang, Guoquiang,McCann, Peggy E.,Mock, Steve,Qureshi, Sajjad A.,Saperstein, Richard,Shen, Xiaolan,Tamvakopoulos, Constantin,Tong, Xinchun,Tota, Laurie M.,Wright, Michael J.,Yang, Xiaodong,Zheng, Song,Chapman, Kevin T.,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.
, p. 4564 - 4569 (2007/10/03)
A novel class of spiro-ureas has been discovered as potent human glucagon receptor antagonists in both binding and functional assays. Preliminary studies have revealed that compound 15 is an orally active human glucagon receptor antagonist in a transgenic
