707-09-5

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 21, p. 477, 1984 DOI: 10.1002/jhet.5570210242

InChI:InChI=1/C9H14N2O2/c1-11-7(12)9(10-8(11)13)5-3-2-4-6-9/h2-6H2,1H3,(H,10,13)

Upstream product

• 186581-53-3 diazomethane 
• 702-62-5 spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione 
• 77-78-1 dimethyl sulfate 
• 4507-57-7 methyl 1-aminocyclohexanecarboxylate 
• 624-83-9 methyl isocyanate 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Chemical Reactions of Cycloalkanespirohydantoins. Part 2. Synthesis of New 4-Hydroxyimidazolidinone N3-Substituted from Cycloalkanespirohydantoins

N3-Substituted hydantoins have been to undergo lithium aluminum hydride reduction (THF, room temperature, 5 hours) to give 4-hydroxy-2-imidazolidinones in good yields.

Method of treating asthma with alkyl, alkylidene and alkylene hydantoins

Pharmaceutical formulations are described, which comprise a hydantoin of formula (I): STR1 wherein R1 is C1-4 alkyl, R2 is hydrogen or C1-4 alkyl; or R1 and R2 taken together either represent a C4-6 alkylene group or a group of formula: STR2 where R5 and R6 independently represent hydrogen or C1-4 alkyl; R3 is C1-6 alkyl or benzyl; R4 is hydrogen or C1-6 alkyl; provided that R2 and R4 cannot both be hydrogen; or R1 and R4 taken together represent a C2-4 alkylene group; associated with a pharmaceutically-acceptable carrier therefor. The compounds, some of which are novel, are useful in the treatment of immediate hypersensitivity diseases such as asthma.