707-36-8

Basic information

• Product Name: 1-Chloro-3,5-dimethyladamantane
• Synonyms: 1-CHLORO-3,5-DIMETHYLADAMANTANE;5-chloro-1,3-dimethyladamantane;1-Chloro-3,5-dimethoxyladamantane;1,3-DiMethyl-5-chloroadaMantane;MeMantine Related CoMpound C;Memantine Related Compound C (50 mg) (1-Chloro-3,5-dimethyladamantane);Memantine USP RC C;1-Chloro-3,5-dimethyladamantane 95%
• CAS NO: 707-36-8
• Molecular Formula: C₁₂H₁₉Cl
• Molecular Weight: 198.73
• EINECS: 1312995-182-4
• Product Categories: Adamantane derivatives;Adamantanes;Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 707-36-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 87 °C / 4mmHg
• Flash Point: 93 °C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0.0583mmHg at 25°C
• Refractive Index: n/D1.4962
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-Chloro-3,5-dimethyladamantane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3,5-dimethyladamantane(707-36-8)
• EPA Substance Registry System: 1-Chloro-3,5-dimethyladamantane(707-36-8)

Safety Data

• RIDADR: UN 1993 / PGIII
• Hazardous Substances Data: 707-36-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 707-36-8 differently. You can refer to the following data:
1. 1-Chloro-3,5-dimethyladamantane is an adamantane derivative used in the preparation of organosilicon compounds with antiviral activity. Memantine impurity C.
2. Building block has been shown to be used as a key intermediate in the synthesis of memantine hydrochloride, which was reported to be a FDA approved drug for Alzheimer′s treatment.

InChI:InChI=1/C12H19Cl/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8H2,1-2H3

Upstream product

• 702-79-4 1,3-dimethyladamantane 
• 707-37-9 1,3-dimethyl-5-adamantanol 
• 941-37-7 3,5-dimethyl-1-bromoadamantane 
• 19982-07-1 1-acetamido-3,5-dimethyladamantane 

Downstream Products

• 19982-07-1 1-acetamido-3,5-dimethyladamantane 
• 351329-88-9 1-formamido-3,5-dimethyltricyclo[3.3.1.1^3,7]decane 
• 41100-52-1 memantine hydrochloride 
• 702-79-4 1,3-dimethyladamantane 

Relevant articles and documents

Improvement method for synthesis process of memantine hydrochloride

The invention discloses an improvement method for a synthesis process of memantine hydrochloride; with 1,3-dimethyl adamantane as a raw material, 3,5-dimethyl-1-adamantanol is obtained through a bromination reaction and a hydrolysis reaction; 3,5-dimethyl-1-adamantanol is subjected to a chlorination reaction to obtain 1-chloro-3,5-dimethyl adamantane; and 1-chloro-3,5-dimethyl adamantane is subjected to an ammoniation reaction, acid hydrolysis and salt formation, and the target product of methamine hydrochloride is produced, wherein in the bromination reaction, the reaction molar ratio of 1,3-dimethyl adamantane and bromine is 1:1.1, the reaction is performed in dichloroethane, and after the hydrolysis reaction, an organic phase is separated and washed to remove bromine and washed and dried, and an obtained solution is directly used for a next reaction. The improvement method provided by the invention can improve the yield, increase reaction safety and reduce waste and waste water.

PROCESS FOR PREPARING MEMANTINE

A process for preparing memantine or an acid addition salt of memantine comprises reacting 1-bromo-3,5-dimethyl adamantane with formamide to form 1-N-formyl-3,5-dimethyl adamantane.