70734-98-4

Upstream product

• 100-01-6 4-nitro-aniline 
• 114090-39-0 cis-4-(4-nitrophenylazo)aniline 
• 4485-08-9 4-nitrosonitrobenzene 
• 106-50-3 1,4-phenylenediamine 

Downstream Products

• 1346264-52-5 (E)-azulen-1-yl-[4-(4-nitrophenyl)azophenyl]diazene 
• 1346264-53-6 (E)-[4-(4-nitrophenyl)azophenyl]-(4,6,8-trimethylazulen-1-yl)diazene 
• 1346264-56-9 4-[4-(4,6,8-trimethylazulen-1-yl)azophenyl]azoaniline 
• 1346264-55-8 4-(4-azulen-1-ylazophenyl)azoaniline 
• 1346264-54-7 (E)-(5-isopropyl-3,8-dimethylazulen-1-yl)-[4-(4-nitrophenyl)azophenyl]diazene 
• 1129300-85-1 C₁₄H₉F₃N₄O₃ 
• 306763-46-2 4-ethynyl-4'-nitroazobenzene 

Relevant academic research and scientific papers

Host-guest complexes of cucurbituril with 4-amino-4′-nitroazobenzene and 4,4′-diaminoazobenzene in acidic aqueous solutions

The thermodynamics and kinetics of the reaction of cucurbituril (Cuc) with 4-amino-4′-nitroazobenzene (DO3) and 4,4′-diaminoazobenzene (Diam) have been studied in aqueous HCl, and it is shown that DO3 is well suited as an indicator for uncomplexed Cuc (actual concentration of Cuc) and Diam is well suited as an indicator for the total concentration of Cuc (sequestering agent) in aqueous solutions. The formation of 1:1 guest-host complexes is observed. For proton concentrations up to 1 mol dm-3, DO3 reacts according to eqn. (a), with the values for the dissociation constant of DO3H+ log(Ka/dm3 mol-1) = CucH+ + DO3H22+ ? CucH+ + DO3H+ + H+ ? CucH+ + DO3 + 2H+ ? CucDO3H+ + 2H+ (a) -2.42, DO3H22+ log(Kb/dm3 mol-1) = 0.53, for the stability constant of CucDO3H+ log (Kc/mol dm3) = 8.05 and for the rate constant of complex formation log (kf/dm3 mol-1 s-1) = 5.25. Reaction enthalpies and activation energies have also been determined. The complexation of Cuc with Diam has been studied in 0.1-1 mol dm-3 HCl where a very strong complexation has been observed.

Light-Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum

The histamine H1 G protein-coupled receptor (GPCR) plays an important role in allergy and inflammation. Existing drugs that address the H1 receptor differ in their chemical structure, pharmacology, and side effects. Light-controllable spatial and temporal activity regulation of photochromic H1 ligands may contribute to a better mechanistic understanding and the development of improved correlations between ligand structure and pharmacologic effects. We report photochromic H1 receptor ligands, which were investigated in an organ-pharmacological assay. Initially, five photochromic azobenzene derivatives of reported dual H1–H4 receptor antagonists were designed, synthesized, photochemically characterized, and organ-pharmacologically tested on the isolated guinea pig ileum. Among them, one compound [trans-19: (Z)-1-(4-chlorophenyl)-1-(4-methylpiperazin-1-yl)-N-(4-((E)-phenyldiazenyl)phenyl)methanimine] retained the antagonistic activity of its non-photochromic lead, and trans–cis isomerization by irradiation induced a fourfold difference in the pharmacological response. Further structural optimization resulted in two bathochromically shifted derivatives of 19 [NO2-substituted 35 {(Z)-1-(4-chlorophenyl)-1-(4-methylpiperazin-1-yl)-N-(4-((E)-(4-nitrophenyl)diazenyl)phenyl)methanimine} and SO3?-substituted 41 {4-((E)-(4-(((Z)-(4-chlorophenyl)(4-methylpiperazin-1-yl)methylene)amino)phenyl)diazenyl)benzenesulfonate}], which do not require the use of UV light for photoisomerization and which also have improved solubility and show reduced tissue impairment. The trans isomers of both compounds showed a remarkable increase in antagonistic activity relative to their lead trans-19; furthermore, a 46-fold difference in activity on the isolated guinea pig ileum was observed between trans- and cis-35.

Azobenzene-benzoylphenylureas as photoswitchable chitin synthesis inhibitors

Benzoylphenylureas (BPUs) are used as synthetic insect growth regulators for inhibiting chitin synthesis. Merging insecticidal BPUs with photoswitchable azobenzene generated photoresponsive chitin synthesis inhibitors. A prepared azobenzene-benzoylphenylurea can be activated upon irradiation with UV light, and shows 6-fold and 2-fold activity difference to armyworm (Mythimna separata) and German cockroach (Blattella germanica) sulfonylurea receptors, respectively. This is the first example of a photoswitchable BPU insecticide. The generation of such a photoresponsive BPU insecticide allows for modulation of the insecticidal activity by light, and may facilitate the spatiotemporal control over the sulfonylurea receptor and the mechanistic study of this kind of insecticide.

Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

Peptide-based diblock and triblock dispersants and diblock polymers

Peptides have been identified that bind with high affinity to common ink pigments and to various print media, including paper and fabrics. These peptides were used to prepare diblock and triblock dispersants for coating applications, including ink jet printing, and diblock polymers for treating paper and fabrics. The diblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, a pigment-binding peptide coupled to a print medium-binding peptide or a print medium-binding peptide coupled to a hydrophobic linker. The diblock polymers consist of a print medium-binding peptide coupled to a hydrophilic linker or a benefit agent. The triblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, which is coupled to a print medium-binding peptide.

Rate constants of the thermal cis-trans isomerization of azobenzene dyes in solvents, acetone/water mixtures, and in microheterogeneous surfactant solutions

Rate constants kiso of the thermal cis-trans isomerization of four 4,4′-nitro-aminoazobenzenes with different amino groups have been determined in homogeneous aprotic solvents and polyglykol oligomers, primarily by means of conventional flash photolysis. The rate constants have been correlated with polarity (according to λmax from UV/Vis absorption spectra of the trans isomers) and bulk viscosity of the solvents. Qualitative conclusions about the influence of varying concentrations of water with respect to polarity and hydrogen bonding on kiso- and λmax-values in acetone/water mixtures were derived. Based on these results the data from microheterogeneous solutions have been interpreted. In microheterogeneous water/surfactant solutions kiso-values of selected azo dyes were strongly dependent on the concentrations of SDS, Triton X-100, C12EO8 in water, and varied with the composition of bicontinuous microemulsions of Igepal CA-520/heptane/water. The large spread of isomerization rate constants is in part due to varying microviscosity. Replacement of H2O by D2O in aqueous surfactant solutions produced surprisingly large kinetic solvent isotope effects.

Insecticide evaporator comprising a stabilizer

Insecticide evaporator comprising at least one volatile phosphoric ester insecticide, an agent for stabilizing the said ester against decomposition by protonization and used in an amount of 0.2 to 20% based on the weight of phosphoric ester, characterized in that the stabilizing agent contains at least one compound selected from the compounds of the chemical class of 1,3-benzodioxoles and at least one diazene.

Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator

An evaporator system adapted for emitting insect killing vapors of an insecticide therefrom and comprising a liquid or solid composition enclosed therein, said insecticide consisting in at least one volatile phosphoric acid ester which is stabilized by at least one diazene compound.