70735-04-5

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 106-50-3 1,4-phenylenediamine 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 138-89-6 p-dimethylaminonitrosobenzene 

Downstream Products

• 765303-90-0 4-{6-[(E)-(4-{(E)-[4-(dimethylamino)phenyl]diazenyl)phenyl)-diazenyl]-2,3-dihydro-1H-perimidin-2-yl}-phenol 
• 1370357-93-9 (Z)-4-(anthracen-2-yl)-4-[4-({E}-{4-(dimethylamino)phenyl}diazenyl)phenylamino]-1,1,1-trifluorobut-3-en-2-one 

Relevant academic research and scientific papers

Visible-light photoresponsivity of a 4-(dimethylamino)azobenzene unit incorporated into single-stranded DNA: Demonstration of a large spectral change accompanying isomerization in DMSO and detection of rapid (Z)-to-(E) isomerization in aqueous solution

We demonstrate significant visible-light photoresponsivity in a synthesized oligonucleotide containing a built-in pseudonucleotide possessing a 4-(dimethylarnino)azobenzene (4-DMAzo) side chain. In dry DMSO as solvent, two clearly distinguishable spectra corresponding to the (E) and (Z) forms of the 4-DMAzo moiety tethered to the oligonucleotide were recorded with a conventional spectrophotometer before and after irradiation with 420 nm wavelength light, which induced (E)-to-(Z) isomerization. In addition, (Z)-to-(E) isomerization was accelerated by irradiation with either visible (λ = 550 nm) or UV (λ = 350 nm) light, demonstrating reversible photoresponsivity of the pseudo-ohgonucleotide. In aqueous solutions the (Z)-to-(E) thermal isomerization of the photoresponsive pseudo-ohgonucleotide was very rapid and was only detectable by laser flash photolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Azo aryl urea derivative, and preparation method and application thereof

The invention relates to an azo aryl urea derivative, and a preparation and an application thereof, and concretely discloses a compound represented by formula (I), or an optical isomer, a cis-trans-isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. Definitions of substituent groups in the general formula are described in the specification and claims. The invention further discloses a composition containing the above compound, and an application thereof. The compound has excellent anticancer activity on HepG2 liver cancer cells, MGC803 gastric cancer cells,HCT116 colon cancer and the like.

Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

Studies on UV/VIS Absorption Spectra of Azo Dyes. XV. An Analysis of the Absorption Spectra of 4,4'-Diaminoazobenzenes

In the visible absorption spectrum 4,4'-bis-diethylaminoazobenzene shows two absorption maxima (λmax = 426 nm and λmax = 477 nm) with high intensity.Quantum chemical calculations and examinations by peak separation of six 4-substituted azobenzenes and six 4'-substituted 4-diethylaminoazobenzenes (1a-k) indicate that the longest wavelenght band is due to a n-?* transition and the other band is due to a ?-?*-transition.This is verified using an inrement system for ?-?* absorption maxima.A linear relation is found between intensity ratios of the two bands and the HAMMETT-?-constants of the substituents.With increasing electron releasing tendency of the substituents the absorption intensity of the n-?*-band increases.