70762-80-0

Basic information

• Product Name: 2-(4-chloro-2-methylphenoxy)-1-phenylethanone
• Synonyms: 2-(4-chloro-2-methylphenoxy)-1-phenylethanone
• CAS NO: 70762-80-0
• Molecular Weight: 260.72
• Mol File: 70762-80-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-2-methylphenoxy)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-2-methylphenoxy)-1-phenylethanone(70762-80-0)
• EPA Substance Registry System: 2-(4-chloro-2-methylphenoxy)-1-phenylethanone(70762-80-0)

Safety Data

• Hazardous Substances Data: 70762-80-0(Hazardous Substances Data)

Usage

Chemical classification

It is a synthetic chemical compound.

Primary use

Clofencet is used as an herbicide to control weeds.

Target weeds

It is effective in controlling wild oats and other grassy weeds in cereal crops such as wheat, barley, and oats.

Mode of action

The herbicide works by inhibiting the production of fatty acids in target plants, disrupting their cellular membranes, and ultimately causing their death.

Application method

It is typically applied to the soil or foliage using sprayers.

Environmental concerns

Clofencet has potential harm to aquatic organisms and other non-target species, so its use should be carefully managed to minimize environmental impact.

Upstream product

• 1570-64-5 2-methyl-4-chlorophenol 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 639011-02-2 (E,Z)-2-(4-chloro-2-methylphenoxy)-1-phenylethanone oxime 

Relevant articles and documents

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels

Optically active mexiletine analogues were synthesized and evaluated in vitro as use-dependent blockers of skeletal muscle sodium channels. The mexiletine analogues were obtained by replacing either the methyl group on the stereogenic center of mexiletine [1-(2,6-dimethylphenoxy)propan-2-amine] with a phenyl group or modifying the phenoxy moiety (by removal of one or both of the methyl groups, or introducing a chlorine atom), or both. The voltage clamp recordings showed that, regardless of the substitution pattern of the aryloxy moiety, all the compounds bearing a phenyl group on the stereogenic center (3a-f) were more active than mexiletine both in tonic and phasic block. This observation was in contrast with what was observed for mexiletine, where the removal of both methyls from the aryloxy moiety caused a dramatic reduction of potency. The most potent congener, (R)-2-(2-methylphenoxy)-1-phenyle-thanamine [(R)-3b], was 27-fold more potent than (R)-mexiletine in producing a tonic block, i.e., the reduction of peak sodium current in resting conditions after application of the compound. (R)-3b maintained a use-dependent behavior, being 23-fold more potent in condition of high frequency of stimulation (phasic block). Despite what was observed with mexiletine, the stereoselectivity held in phasic block conditions. Stereoselectivity indexes were generally low, ranging from 1 to 4, but except for that of the 2,6-xylyloxy congener 3c, they were higher for the congeners bearing a phenyl ring on the stereogenic center than for mexiletine and its strictly related analogue 1-methyl-2-phenoxyethanamine (1). This finding was in agreement with Pfeiffer's rule. The introduction of a chlorine atom in the 4-position of the aryloxy moiety caused a reduction of potency and a reversal of stereoselectivity as well. On the basis of the model to date accepted for the sodium channel local anesthetic-like molecule receptor, some possible explanations of our observations will be proposed.