70786-10-6Relevant academic research and scientific papers
Silver-Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids
Tian, Miao,Yu, Mingwu,Shi, Tingting,Hu, Junbin,Li, Shunlai,Xu, Jiaxi,Chen, Ning,Du, Hongguang
, p. 3415 - 3420 (2017)
A practical and operationally simple protocol for the assembly of 6-aryl-substituted purines through the direct C6–H arylation of purines and 8-azapurine and purine nucleosides from arylboronic acids was developed. This reaction was performed under ambient conditions with ammonium persulfate as the oxidant in the presence of silver(I). The reaction was found to be regioselective with the arylation occurring predominantly at the C6 position, and a large variety of functional groups, including halides, esters, hydroxy groups, and heterocycles, were tolerated.
Microwave promoted palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of 6-chloropurines with sodium tetraarylborate in water
Qu, Gui-Rong,Xin, Peng-Yang,Niu, Hong-Ying,Jin, Xin,Guo, Xiao-Ting,Yang, Xi-Ning,Guo, Hai-Ming
experimental part, p. 9099 - 9103 (2011/12/01)
An efficient method for the synthesis of 6-arylpurines (nucleosides) was developed via Suzuki-Miyaura cross-coupling reactions of 6-chloropurines (nucleosides) and sodium tetraarylborate in neat water (ethanol). The process gave good to high isolated yiel
