708-65-6

Usage

Molecular structure

A benzene ring with a methyl group (CH3) attached to the 4th carbon and a 1-chloro-2,2,2-trifluoroethyl group attached to the 1st carbon

Physical state

Clear, colorless liquid

Odor

Sweet, pungent

Flammability

Highly flammable

Uses

a. Solvent in various industries
b. Precursor in the production of chemicals, pharmaceuticals, dyes, and explosives
c. Industrial feedstock
d. Found in consumer products like paint thinners, adhesives, and nail polish removers

Health hazards

Inhalation of vapors can cause headaches, dizziness, and potential brain and nervous system damage in extreme cases

Safety precautions

Handle with care and avoid inhalation of vapors

Environmental impact

Toxic to aquatic life and should be disposed of properly to prevent environmental contamination

Upstream product

• 381-44-2 bis(2,2,2-trifluoroethyl) chlorophosphate 
• 446-65-1 2,2,2-trifluoro-1-(4-methylphenyl)ethanol 
• 384-65-6 1-chloro-2,2,2-trifluoroethylbenzene 
• 128408-26-4 C₉H₈F₃⁽¹⁺⁾ 

Downstream Products

• 507-20-0 tertiary butyl chloride 
• 128408-26-4 C₉H₈F₃⁽¹⁺⁾ 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Relevant academic research and scientific papers

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

A Stille cross-coupling reaction was developed that delivers for the first time trifluoromethyl-substituted homoallyl compounds from α-(trifluoromethyl)benzyl chlorides and allylstannanes. This reaction proceeds even with low catalyst loadings (1 mol%) vi

An efficient dehyrohalogenation method for the synthesis of α,β,β-trifluorostyrenes, α-chloro-β,β- difluorostyrenes and E-1-arylperfluoroalkenes

Dehydrofluorination of 1-aryl-1,2,2,2-tetrafluoroethanes (ArCHFCF 3) and 1-aryl-1-chloro-2,2,2-trifluoroethane (ArCHClCF3) using lithiumhexamethyldisilazide (LHMDS) in tetrahydrofuran (THF) at room temperature produced 1,2,2-trifluorostyrene and 1-chloro-2,2-difluorostyrene, respectively, in very good isolated yields. Dehydrofluorination of 1,2,2,3,3,3-hexafluoro-1-phenyl-propane (PhCHFCF2CF3) and 1,2,2,3,3,4,4,4-octafluoro-1-phenyl-butane (PhCHFCF2CF 2CF3) using LHMDS produced the corresponding substituted olefins (1-phenyl-1,2,3,3,3-pentafluoroprop-1-ene and 1-phenyl-1,2,3,3,4,4,4- pentafluorobut-1-ene) in good yield and high E-selectivity. Dehydrofluorination of 1-chloro-1-phenyl-2,2,3,3,3-pentafluoropropane (PhCHClCF2CF 3) and 1-chloro-1-phenyl-2,2,3,3,4,4,4-heptafluorobutane (PhCHClCF2CF2CF3) produced a mixture of the corresponding E and Z olefins (PhCClCFCF3 and PhCClCFCF 2CF3) in good yield.

Gas phase substituent effects. Stabilities of 1-aryl-2,2,2-trifluoroethyl cations

Gas-phase stabilities of 1-aryl-2,2,2-trifluoroethyl cations were determined based on chloride-transfer equilibria. The substituent effect was analyzed based on the LArSR Eq., giving a remarkably high r of 1.53 and a ρ of -14.6.

CATALYTIC PHOSPHORYLATION OF POLYFLUOROALKANOLS. 15. CATALYTIC PHOSPHORYLATION OF α-POLYFLUOROALKYLBENZYL ALCOHOLS BY BIS(POLYFLUOROALKYL) CHLOROPHOSPHATES

The catalytic phosphorylation of α-polyfluoroalkylbenzyl alcohols by bis(polyfluoroalkyl) chlorophosphates is a convenient method for the synthesis of various bis(polyfluoroalkyl)(α-polyfluoroalkylbenzyl) phosphates, including those having donor substituents in the benzene ring.It was shown that in the series of p-methyl-α-trifluoromethylbenzyl phosphates p-CH3C6H4CH(CF3)OP(O)XY (where X, Y = Cl, CF3CH2O), the ability to act as O-alkylating agents with respect to polyfluorinated alcohols is a common characteristic, and the alkylating ability increases symbatically with increase in the overall electron-acceptor strength of the X and Y substituents at the phosphorus atom.