708-65-6

Basic information

• Product Name: 1-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzene
• CAS NO: 708-65-6
• Molecular Formula: C₉H₈ClF₃
• Molecular Weight: 208.608
• Mol File: 708-65-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 181.8°C at 760 mmHg
• Flash Point: 67.1°C
• Density: 1.248g/cm³
• Vapor Pressure: 1.14mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: 1-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzene(708-65-6)
• EPA Substance Registry System: 1-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzene(708-65-6)

Safety Data

• Hazardous Substances Data: 708-65-6(Hazardous Substances Data)

Usage

Molecular structure

A benzene ring with a methyl group (CH3) attached to the 4th carbon and a 1-chloro-2,2,2-trifluoroethyl group attached to the 1st carbon

Physical state

Clear, colorless liquid

Odor

Sweet, pungent

Flammability

Highly flammable

Uses

a. Solvent in various industries
b. Precursor in the production of chemicals, pharmaceuticals, dyes, and explosives
c. Industrial feedstock
d. Found in consumer products like paint thinners, adhesives, and nail polish removers

Health hazards

Inhalation of vapors can cause headaches, dizziness, and potential brain and nervous system damage in extreme cases

Safety precautions

Handle with care and avoid inhalation of vapors

Environmental impact

Toxic to aquatic life and should be disposed of properly to prevent environmental contamination

Upstream product

• 381-44-2 bis(2,2,2-trifluoroethyl) chlorophosphate 
• 446-65-1 2,2,2-trifluoro-1-(4-methylphenyl)ethanol 
• 384-65-6 1-chloro-2,2,2-trifluoroethylbenzene 
• 128408-26-4 C₉H₈F₃⁽¹⁺⁾ 

Downstream Products

• 507-20-0 tertiary butyl chloride 
• 128408-26-4 C₉H₈F₃⁽¹⁺⁾ 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Relevant articles and documents

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

A Stille cross-coupling reaction was developed that delivers for the first time trifluoromethyl-substituted homoallyl compounds from α-(trifluoromethyl)benzyl chlorides and allylstannanes. This reaction proceeds even with low catalyst loadings (1 mol%) vi

Gas phase substituent effects. Stabilities of 1-aryl-2,2,2-trifluoroethyl cations

Gas-phase stabilities of 1-aryl-2,2,2-trifluoroethyl cations were determined based on chloride-transfer equilibria. The substituent effect was analyzed based on the LArSR Eq., giving a remarkably high r of 1.53 and a ρ of -14.6.