708-90-7

Upstream product

• 917-64-6 methyl magnesium iodide 
• 4073-31-8 (diethylamino)phenylchlorophosphine 
• 75231-54-8 Methylphenyl-thiophosphinsaere-diethylamid 
• 644-97-3 Dichlorophenylphosphine 
• 917-54-4 methyllithium 

Downstream Products

• 15849-86-2 methyl(phenyl)chlorophosphine 
• 38851-76-2 methyl-(1-naphthyl)(phenyl)phosphine 
• 24153-87-5 Benzyl-methyl-naphthalen-1-yl-phenyl-phosphonium; bromide 
• 19432-40-7 Benzylmethyl(1-naphthyl)phenylphosphonium-chlorid 
• 19432-37-2 Benzylidene-methyl-naphthalen-1-yl-phenyl-λ⁵-phosphane 
• 84673-94-9 (2S,3S)-2,3-Bis-benzoyloxy-3-carboxy-propionatebenzyl-methyl-naphthalen-1-yl-phenyl-phosphonium; 

Relevant academic research and scientific papers

P-stereogenic wide bite angle diphosphine ligands

Two modular synthetic approaches for the preparation of novel wide bite angle diphosphine ligands containing stereogenic P-atoms have been developed, leading to compounds (S,S)-2,2′-bis(methylphenylphosphino)diphenyl ether (L1) and (S,S)-2,2′-bis(ferrocen

Reactions with Phosphine Alkylenes, XLI. Resolution of Chiral Phosphonium Salts

The preparation and resolution of chiral phosphonium salts 1a - c via the corresponding phosphonium ylides is described.

PHOSPHORORGANISCHE VERBINDUNGEN 91 Entschwefelungsstudien an optisch aktiven Thiophosphinsaerederivaten mit dem Ziele der Darstellung optisch aktiver Phosphinigsaerederivate

Chiral phosphinous acid derivatives 4 MePhPX(X = OR, SR) were not obtained following desulphurization of optically active thiophosphinic acid esters 3(X = OR, SR), where sodium/liquid NH3, sodium-naphthalide (THF), potassium, trimethylphosphine, tributylphosphine, or cathodic fassion were employed as agents.The barrier to inversion in phosphinous acid derivatives is obviously small.

PHOSPHORORGANISCHE VERBINDUNGEN 90 Methodische Ausgestaltung der P-C und P-S-Cyanolyse am Beispiel einiger Heterophosphoniumsalze

Treatment of allylamido-phosphonium salts with dry tetrabutylammonium cyanide in methylenechloride delivers after removal of the allyl group phosphinous acid amides with retention of configuration (P-C-cyanolysis).Allyl-O-alkylphosphonium salts undergo the Arbosov reaction under the above conditions, while allyl-S-alkyl phosphonium salts undergo fission of the P-S bond (P-S cyanolysis).Equally good results were obtained using KCN in methylene chloride accompained by catalytic amounts of 18-crown-6 ether; thus optically active benzyl-methyl-phenyl-phosphine-sulfid gave the corresponding phosphine with retention of configuration.Dithiophosphinic acid esters and thiophosphinic acid amides, after conversion to the corresponding quasiphosphonium salts via S-alkylation and subsequent treatment with tetrabutylammonium cyanide in methylenechloride, also give the corresponding thiophosphinous acid ester and phosphinous acid amide respectively.Thiophosphinic acid O-alkyl esters (R2P(S)OR') give however the thiophosphinic S-alkyl ester (R2P(O)SR') via an Arbusov reaction.The P-C cyanolysis of allyl-triphenylphosphoniumbromide using KCN/18-crown-6 or tetrabutylammonium cyanide in aprotic medium stops at the stage of the intermediary red-coloured ylide; addition of a proton-donor then results in the subsequent rearrangement to the corresponding propenyl-phosphonium salt.