70803-96-2

Usage

Uses

Used in Pharmaceutical Industry:
7-BENZOYLINDOLE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 7-BENZOYLINDOLE is utilized as a precursor in the production of agrochemicals, playing a crucial role in the creation of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
7-BENZOYLINDOLE is employed as a precursor in the synthesis of other organic compounds, highlighting its versatility in chemical reactions and its importance in the field of organic chemistry.
Used in Biological Research:
7-BENZOYLINDOLE is studied for its potential biological activities, such as its role as a neuroprotective agent, which may contribute to the development of treatments for neurological disorders, and as an anti-inflammatory agent, which could be beneficial in managing inflammatory conditions.

Upstream product

• 187099-53-2 (2-Benzoyl-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester 
• 615-43-0 2-iodophenylamine 
• 120-72-9 indole 
• 611-73-4 Benzoylformic acid 
• 134-81-6 benzil 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 3834-66-0 (4-fluorophenyl)phenylethanedione 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 98-80-6 phenylboronic acid 
• 1647059-06-0 C₁₇H₂₄N₂O₂Si 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 1623752-20-4 5-((tert-butyldimethylsilyl)oxy)-1-phenylpent-2-en-1-one 
• 100-47-0 benzonitrile 
• 496-15-1 1-indoline 

Downstream Products

• 76049-81-5 3-chloro-7-benzoylindole 
• 51135-38-7 7-benzoyl-1,3-dihydroindol-2-one 
• 61941-56-8 2-amino-3-benzoylbenzeneacetic acid,sodium salt 
• 116764-07-9 <3-<(dimethylamino)methyl>-1H-indol-7-yl>phenylmethanone 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct and Specific C-7 Acylation of Indolines with 1,2-Diketones

The indole scaffold is a ubiquitous and useful substructure, and extensive investigations have been conducted to construct the indole framework and/or realize indole modification. Nevertheless, the direct selective functionalization on the benzenoid core must overcome the high activity of the C-3 position and still remains highly challenging. Herein, a palladium-catalyzed direct and specific C-7 acylation of indolines in the presence of an easily removed directing group was developed. This strategy usually is considered as a practical strategy for the preparation of acylated indoles because indoline can be easily converted to indole under oxidation conditions. In particular, our strategy greatly improved the alkacylation yield of indolines for which only an unsatisfactory yield could be achieved in the previous studies. Furthermore, the reaction can be scaled up to gram level in the standard reaction conditions with a much lower palladium loading (1 mol %).

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses

Rhodium enalcarbenoids: Direct synthesis of indoles by rhodium(II)- catalyzed [4+2] benzannulation of pyrroles

Disclosed herein is the design of an unprecedented electrophilic rhodium enalcarbenoid which results from rhodium(II)-catalyzed decomposition of a new class of enaldiazo compounds. The synthetic utility of these enalcarbenoids has been successfully demonstrated in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles, thus leading to substituted indoles. The new benzannulation has been applied to the efficient synthesis of the natural product leiocarpone as well as a potent adipocyte fatty-acid binding protein inhibitor. Fat cat: A new class of enaldiazo compounds resulted in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles to deliver indoles. The benzannulation is proposed to involve an unprecedented diacceptor rhodium enalcarbenoid. The reaction was used in the highly efficient synthesis of the natural product leiocarpone and a potent adipocyte fatty-acid binding protein inhibitor.

A concise synthesis of 7-substituted indoles

7-Substituted indoles were synthesized by the basic cyclization of 6-substituted tert-butyl 2-(trimethylsilyiethynyl)phenylcarbamates which were derived by the lithiation of tert-butyl 2- (trimethylsilylethynyl)phenylcarbamate and the subsequent reaction with electrophiles.

Process for the production of 7-acylindoles

A process for the production of 7-acylindoles of the general formula: STR1 starting from indoline of the formula: STR2 Indoline is cyanized in a first stage to 7-cyanoindoline of the formula: STR3 The latter is catalytically dehydrogenated in a second stage to 7-cyanindole of the formula: STR4 The latter is then acylated in a third stage with an organometallic compound of the formula: into the end product according to formula I.