70806-40-5Relevant academic research and scientific papers
Potential antimalarials. XXII Some 2,4-diamino-5-(3- and 4-trifluoromethylphenyl and 3,4-methylenedioxyphenyl)pyrimidines
Barlin, Gordon B.,Kotecka, Barbara,Rieckmann, Karl H.
, p. 647 - 650 (2007/10/03)
A series of 10 pyrimethamine analogues containing 3′- and 4′-trifluoromethyl and 3′,4′-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine, they were much less active against the drug-resistant K-1 isolate. The 4′-trifluoromethyl compunds, however, showed much smaller differences.
Substituted 6-phenyl-1,2,4-triazolo[4,3-a]pyridines
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, (2008/06/13)
This disclosure describes novel 6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as hypotensive agents.
Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines
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, (2008/06/13)
This disclosure describes novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents.
