70822-79-6

Upstream product

• 70822-55-8 2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-(4-hydroxyphenyl)butane 
• 81278-42-4 2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-butanone 
• 81278-41-3 2-(4-bromophenyl)-1-(4-hydroxyphenyl)-1-butanone 
• 81278-40-2 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-butanone 
• 67205-73-6 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone 

Downstream Products

• 135247-71-1 (E)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-(4-isopropenylphenyl)-1-butene hydrochloride 
• 135247-70-0 (Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-(4-isopropenylphenyl)-1-butene hydrochloride 
• 133595-66-1 (E)-2-<4-(1,2-dihydroxy-1-methylethyl)phenyl>-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-67-2 (Z)-2-<4-(1,2-dihydroxy-1-methylethyl)phenyl>-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-64-9 (E)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-<4-(2-hydroxy-1-methylethyl)phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-65-0 (Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-<4-(2-hydroxy-1-methylethyl)phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-60-5 (E)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-<4-(1-hydroxy-1-methylethyl)phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-61-6 (Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-<4-(1-hydroxy-1-methylethyl)phenyl>-1-(4-hydroxyphenyl)-1-butene 
• 133595-58-1 (E/Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-<4-(1-hydroxy-1-methylethyl)phenyl>-1-<4-(tetrahydropyran-2-yloxy)phenyl>-1-butene 
• 81278-38-8 <3H>hydroxytamoxifen 
• 81278-39-9 cis-<3H>hydroxytamoxifen 
• 133595-56-9 (E/Z)-2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-<4-(tetrahydropyran-2-yloxy)phenyl>-1-butene 

Relevant academic research and scientific papers

Synthesis of the E and Z Isomers of the Antiestrogen Tamoxifen and Its Metabolite, Hydroxytamoxifen, in Tritium-Labeled Form

Both isomers of the potent antiestrogen tamoxifen (1,2-diphenyl-1-phenyl>-1-butene: E isomer = ICI-47699; Z isomer = ICI-46474, Nolvadex) and its metabolite, hydroxytamoxifen (1-phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene), have been synthesized in a high specific activity, tritium-labeled form by catalytic tritium-halogen exchange performed on brominated precursors.The synthesis of another precursor to labeled tamoxifen which would enable the incorporation of three tritium atoms into the molecule by tritium-halogen exchange is reported.