708295-70-9Relevant academic research and scientific papers
Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase
Hakogi, Toshikazu,Fujii, Shinobu,Morita, Michio,Ikeda, Kiyoshi,Katsumura, Shigeo
, p. 2141 - 2144 (2005)
The sulfur analogue of sphingomyelin was designed and stereoselectively synthesized from S-benzyl-N-Boc-cysteine. The introduction of the phosphoryl choline moiety was successfully achieved by our own method using 2-bromoethyl dimethyl phosphite and carbon tetrabromide followed by a trimethylamine treatment. The synthesized compound proved to be a useful substrate for monitoring the enzyme activity of sphingomyelinase by detecting the liberated thiol group with a thiol-sensitive reagent.
