7088-12-2Relevant academic research and scientific papers
Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents
Aicher, Thomas D.,Balkan, Bork,Bell, Philip A.,Brand, Leonard J.,Cheon,Deems, Rhonda O.,Fell, Jay B.,Fillers, William S.,Fraser, James D.,Gao, Jiaping,Knorr, Douglas C.,Kahle, Gerald G.,Leone, Christina L.,Nadelson, Jeffrey,Simpson, Ronald,Smith, Howard C.
, p. 4556 - 4566 (2007/10/03)
A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. The in vivo hypoglycemic efficacy and potency of these compounds were evaluated in a model of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus), the ob/ob mouse. 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
Synthesis and anticonvulsant activity of some 1,2,3,3α-tetrahydropyrrolo[2,1-b]-benzothiazol-, -thiazol- or -oxazol-1-ones in rodents
Trapani, Giuseppe,Franco, Massimo,Latrofa, Andrea,Carotti, Angelo,Cellamare, Saverio,Serra, Mariangela,Ghiani, Cristina A.,Tuligi, Graziella,Biggio, Giovanni,Liso, Gaetano
, p. 834 - 840 (2007/10/03)
To identify more potent anticonvulsant agents and to gain insights into the structural properties determining the potency of a new class of anticonvulsants, some 3α-substituted tetrahydropyrrolo[2,1-b]benzothiazol-1-ones (1a-d) and the thiazole and oxazol
