70889-83-7

Upstream product

• 128421-96-5 methyl N-<2-(N-benzyloxycarbonyl)aminoethyl>glycinate 
• 441778-88-7 methyl N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycinate 

Downstream Products

• 441778-89-8 [allyloxycarbonyl-(2-{2-[(2-benzyloxycarbonylamino-ethyl)-tert-butoxycarbonyl-amino]-acetylamino}-ethyl)-amino]-acetic acid methyl ester 
• 441778-85-4 [allyloxycarbonyl-(2-{2-[(2-benzyloxycarbonylamino-ethyl)-tert-butoxycarbonyl-amino]-acetylamino}-ethyl)-amino]-acetic acid 
• 441778-84-3 C₅₀H₇₅N₉O₁₄S 
• 1352089-38-3 methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate 
• 1352089-40-7 N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycine 
• 1352089-41-8 N-{9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-15-[(9H-fluoren-9-yl)methyloxycarbonyl]-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl}carbamic acid phenylmethyl ester 
• 1352089-42-9 N-[9-(allyloxycarbonyl)-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester 
• 1352089-43-0 N-[9-(allyloxycarbonyl)-15-{2-[1,6-dihydro-6-oxo-2-(phenylmethoxycarbonylamino)-9H-purin-9-yl]acetyl}-3-(tert-butoxycarbonyl)-20-(morpholin-4-yl)-5,11,17-trioxo-3,6,9,12,15,18-hexaazaicos-1-yl]carbamic acid phenylmethyl ester 
• 1352089-44-1 N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester 

Relevant academic research and scientific papers

Liquid-phase combinatorial synthesis of diPNA-arginine conjugates

Considering the promising anti HIV activity displayed by some diPNA-arginine conjugates, a library has been generated to determine the target(s) and mode(s) of action of these presumed multi targets drugs and to optimize the antiviral properties of lead compounds. This library has been prepared using a combinatorial liquid-phase strategy, involving easily available N-protected PNA dimeric backbones as building blocks.

Improved Large-Scale Liquid-Phase Synthesis and High-Temperature NMR Characterization of Short (F-)PNAs

We report on a large-scale synthesis of F-PNA trimer 10 and PNA trimer 11. The key improvement is the facile two-step synthesis of (2,4-difluoro-5- methylphenyl)acetic acid (2). Water solubility of the corresponding F-PNA oligomer 10 was achieved by synthesizing solubility enhancer 5a, which is twofold positively charged and only consists of inherent structural elements of PNA. Protected and unpaired PNA n-mers exist in a mixture of 2n conformers undergoing slow exchange and leading to complicated NMR spectra. Structure analysis was improved by recording 1H- and 13C-NMR spectra at elevated temperatures above the coalescence point. Fully protected backbone derivatives show sharp resonances where expected, and spectra of protected PNAs are remarkably simplified, thereby allowing an interpretation for the first time. Both trimers 10 and 11 are considered as building blocks for a self-replicating system based on PNA. Copyright