70890-46-9Relevant academic research and scientific papers
3-NITRO-5-R-1,2,4-TRIAZOL-1-YLPROPIONIC ACIDS AND THEIR DERIVATIVES
Kofman, T. P.,Krivosheeva, G. S.,Pevzner, M. S.
, p. 1913 - 1918 (2007/10/02)
The reaction of 3-nitro-5-R-1,2,4-triazoles with acrylic acid and its derivatives and the subsequent transformations of the addition products give 3-nitro-5-R-1,2,4-triazol-1-ylpropionic acids, their esters, and their nitriles.It was noticed that the strongest of the NH acids of the series 3,5-dinitro-1,2,4-triazole (pKa -0.66) had anomalously high reactivity in reactions of the Michael type in comparison with compounds of moderate acidity (pKa 3-7).The latter exhibit the usual increase in reactivity with increase in the pKa value.The structure was modified byheteroaryl substitution with triazolate anions at position 5 in 3,5-dinitro-1,2,4-triazol-1-ylpropionic ester.
