708983-83-9

Basic information

• Product Name: C₉H₁₀N₂S
• Synonyms: C₉H₁₀N₂S
• CAS NO: 708983-83-9
• Molecular Weight: 178.258
• Mol File: 708983-83-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₉H₁₀N₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₁₀N₂S(708983-83-9)
• EPA Substance Registry System: C₉H₁₀N₂S(708983-83-9)

Safety Data

• Hazardous Substances Data: 708983-83-9(Hazardous Substances Data)

Upstream product

• 22246-13-5 6-amino-3,4-dihydro-1H-quinolin-2-one 

Downstream Products

• 708983-84-0 4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-amine 
• 708983-86-2 C₁₇H₁₆N₄ 
• 1421322-00-0 C₁₆H₁₃ClN₄ 
• 1421321-99-4 C₁₆H₁₃ClN₄ 
• 1421322-25-9 C₃₀H₃₁ClN₆O₂ 
• 1421322-24-8 C₂₉H₂₉ClN₆O 
• 1421322-23-7 C₂₉H₂₈Cl₂N₆O 
• 1421322-22-6 C₂₉H₂₈ClFN₆O 
• 1421322-21-5 C₂₉H₂₈ClFN₆O 
• 1421322-16-8 C₃₀H₃₁ClN₆O₂ 
• 1421322-02-2 C₁₈H₁₄Cl₂N₄O 
• 1421322-01-1 C₁₈H₁₄Cl₂N₄O 
• 1384110-84-2 C₂₃H₂₄Cl₂N₆O₂ 
• 1384110-83-1 C₂₃H₂₆N₆O₂ 

Relevant articles and documents

Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro- [1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties

Two series of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7- yl)acetamides bearing piperazine and 1,4-diazepane moieties were synthesized and screened for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. Most of the derivatives exhibited better in vitro positive inotropic activity than the existing drug, milrinone, among which 2-(4-(4-chlorobenzyl)-1,4-diazepan-1-yl)-N-(1-oxo-1,2,4,5- tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamide 6c proved to be the most potent with 15.48 ± 0.27% increased stroke volume (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10-5 M. The chronotropic effects of the compounds that exhibited inotropic effects were also evaluated.

Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides

A series of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl) piperidine-4-carboxamides has been synthesized and evaluated for positive inotropic activity by measuring left atrium stroke volume in isolated rabbit-heart preparation

Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl-n-(4,5-dihydro-1-methyl[1,2,4] triazolo[4,3-a]quinolin-7-yl)-acetamides

In an attempt to search for more potent positive inotropic agents, a series of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5- dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides was synthesized and their positive inotropic activities were evaluated by measuring left atrium stroke volume on isolated rabbit-heart preparations. Several compounds showed favorable activity compared with the standard drug Milrinone among which 2-(4-(4-(2-chlorobenzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4, 5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamide 6e was found to have the most desirable potency with the 6.79 ± 0.18% increased stroke volume (Milrinone: 1.67 ± 0.64%) at a concentration of 1 × 10 -5 M in our in-vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated in this work.