708990-53-8Relevant academic research and scientific papers
Innovative approach for the synthesis of N-substituted amides from nitriles and alcohols using propylphosphonic anhydride (T3P) under solvent-free conditions
Chaithra, Nagaraju,Mantelingu, Kempegowda,Rangappa, Kanchugarakoppal S.,Rangappa, Shobith,Sandhya, Nagarakere C.,Swarup, Hassan A.
, p. 2106 - 2116 (2019)
Novel and convenient methodology for the construction of N-substituted amide derivatives have been developed from nitriles and alcohols using propylphosphonic anhydride (T3P). This methodology is an alternate approach to the synthesis of amides via Ritter reaction, which is one of the classical methods for the synthesis of N-substituted amides from nitriles and alcohols. In this approach, first T3P activates the alcohol which is then attacked by nitrile to form N-substituted amides. This methodology can also apply for the synthesis of benzhydryl ether. This developed protocol is one of the novel applications of T3P.
