709014-13-1Relevant academic research and scientific papers
Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects
Carr, Miriam,Greene, Lisa M.,Knox, Andrew J.S.,Lloyd, David G.,Zisterer, Daniela M.,Meegan, Mary J.
experimental part, p. 5752 - 5766 (2011/02/23)
The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natur
