709015-10-1

Upstream product

• 344765-43-1 4-benzyl-4-tert-butoxycarbonyl-2-azetidinone 
• 33375-06-3 (1R)-1-phenylethyl isocyanate 
• 709015-06-5 (S)-2-Benzyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidine-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

From 1-acyl-β-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors

Starting from the structure of known β-lactam covalent human cytomegalovirus (HCMV) protease inhibitors and from the knowledge of the residues implicated in the active site of this enzyme, we designed a series of phenylalanine-derived 2-azetidinones beari

Synthesis and anti-HCMV activity of 1-acyl-β-lactams and 1-acylazetidines derived from phenylalanine

Different Phe-derived 1-acyl-β-lactams, analogous to a series of 2-azetidinones acting as HCMV serine protease inhibitors, were synthesized. Some of these compounds were modest inhibitors of the HCMV replication. Interestingly, removal of the carbonyl gro