709015-13-4Relevant academic research and scientific papers
From 1-acyl-β-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors
Gerona-Navarro, Guillermo,Pérez De Vega, M. Jesús,García-López, M. Teresa,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Balzarini, Jan,González-Mu?iz, Rosario
, p. 2612 - 2621 (2007/10/03)
Starting from the structure of known β-lactam covalent human cytomegalovirus (HCMV) protease inhibitors and from the knowledge of the residues implicated in the active site of this enzyme, we designed a series of phenylalanine-derived 2-azetidinones beari
Easy access to orthogonally protected α-alkyl aspartic acid and α-alkyl asparagine derivatives by controlled opening of β-lactams
Gerona-Navarro, Guillermo,García-López, Ma. Teresa,González-Mu?iz, Rosario
, p. 6145 - 6148 (2007/10/03)
The controlled opening of the N1-C2 bond in 1-carbamate-substituted 2-azetidinones derived from amino acids by O- and N-nucleophiles provided a straightforward access to orthogonally protected α-alkyl aspartic acid and asparagine derivatives. The use of DBU or sodium azide as additive is essential for expedient cleavage by amino acids to the corresponding β-aspartic acid dipeptides.
