70904-56-2 Usage
Uses
Used in Pharmaceutical Industry:
Kyotorphin is used as a potential analgesic agent for pain regulation in the central nervous system. It facilitates the release of Met-enkephalin and Leu-enkephalin, which are opioids that help inhibit pain signals in the brain.
Used in Neurological Research:
Kyotorphin is used as a research compound to study the mechanisms of pain regulation and the role of opioids in the central nervous system. This can aid in the development of new pain management strategies and therapies.
Used in Drug Delivery Systems:
Kyotorphin is used as a target for the development of drug delivery systems that can overcome the blood-brain barrier challenge. These systems aim to enhance the delivery, bioavailability, and therapeutic outcomes of Kyotorphin in pain management.
Check Digit Verification of cas no
The CAS Registry Mumber 70904-56-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,9,0 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 70904-56:
(7*7)+(6*0)+(5*9)+(4*0)+(3*4)+(2*5)+(1*6)=122
122 % 10 = 2
So 70904-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1
70904-56-2Relevant academic research and scientific papers
SINGLE-STEP SYNTHESIS OF KYOTORPHIN IN FROZEN SOLUTIONS BY CHYMOTRYPSIN
Meos, Helle,Tougu, Vello,Haga, Mati,Aaviksaar, Aavo,Schuster, Matthias,Jakubke, Hans-Dieter
, p. 1559 - 1564 (2007/10/02)
A novel method of Kyotorphin (H-Tyr-Arg-OH) synthesis without protecting and deprotecting procedures is described - α-chymotrypsin-catalyzed aminolysis of H-Tyr-OEt by H-Arg-OH in frozen mixtures.In this one step process yields of the peptide product above 80percent have been obtained.
Method for protecting guanidino group and restoring the same
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, (2008/06/13)
A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzensulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
