70907-50-5Relevant academic research and scientific papers
Cyclohexylphenoxy amidoximes and imidazolines with antidepressive and α-adrenergic activity
Picciola,Carissimi,Ravenna,Gentili,Carenini
, p. 729 - 738 (2007/10/05)
The effect of variation of the cycloaliphatic residue position on pharmacological activity was studied in two series of cyclohexylphenoxy derivatives (A and B). The ortho derivatives generally exhibit remarkably strong activity; (A) has an imipramine-like pharmacological profile; (B) with Y = H is more active than naphazoline and xylomethazoline as vasocontrictor. The meta and para substituted derivatives and all (B) derivatives with R=CH3 exhibit no definite or interesting pharmacological activities.
