70911-04-5

Upstream product

• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 

Downstream Products

• 1240383-87-2 4-[(2-phenylethyl)sulfanyl]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one 

Relevant academic research and scientific papers

Analogues of antidepressants - Synthesis of new 4-amine derivatives of 10,11-dihydro-5H-dibenzo[a,d]cycloheptane

In this paper the synthesis of six new 10,11-dihydro-5H-dibenzo[a,d]cycloheptane derivatives, analogues of antidepressants agents are reported. The preparation involved the initial introduction of the iodine atom in the positon 4 of the dibenzosuberone 3 to give the compound 4, which was then treated with different nuclcophilic reagents, to produce the compounds 5a to 5f.

Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test

This study investigated the antidepressant-like effect of 4-amine derivatives of 10,11-dihydro-5H-dibenzo-alkylamine-cycloheptane, 4-amine (3-N,N-dimethylpropylamine)-10,11-dihydro-5H-dibenzo[a,d]cycloheptane-5-one (ADDCH1) and 1,2,3,4,8,9-hexahydro-dibenzocyclohepta[4,4a,5-ef]1,4-diazepin (ADDCH2), in a validated experimental model of depression, the forced swimming test (FST) in mice. Female adult mice were sub-chronically (three doses in 24 h) or repeatedly (once a day for 10 days) treated with either of the compounds and evaluated in the FST. The sub-chronic treatment promoted a dose-dependent reduction in the immobility time in the FST with the doses of 50 mg/kg (ADDCH1) and 30 mg/kg (ADDCH2) ip being the most effective (33% and 37% of reduction, respectively). A similar profile of action was observed in the animals repeatedly treated with ADDCH1 50 mg/kg or ADDCH2 30 mg/kg ip (for 10 days) and there was no sign of motor impairment or locomotor activation as evaluated in the rota-rod and open-field tests, respectively. These findings suggest that these amine derivatives of the system dibenzocycloheptane have an antidepressant-like action which could be of clinical interest and, therefore, deserves further investigation. In addition, putative underlying mechanisms of action are discussed.

4-Thio derivatives of dibenzosuberone: Potential antidepressant compounds

This work describes the synthesis of a series of nine 4-thio dibenzosuberone derivatives (10,11-dihydro-5Hdibenzo[ a,d]cycloheptane-5-one derivatives). Ullmann's reaction was used to synthesize six 4-thio dibenzosuberone derivatives 10-15 from 4-iodo dibe

Synthesis of a new benzocycleheptaquinoline system

The new heterocyclic benzocycloheptaquinoline 8a was synthetized with 44% yield, starting with dibenzosuberone 3 in five steps. The linear isomer was totaly identified by IR, NMR 1H and 13C and MS, spectroscopic methods.