70912-53-7Relevant academic research and scientific papers
Synthesis of [1,2-A]-fused tricyclic dihydroquinolines by palladiumcatalyzed intramolecular C-N cross-coupling of polarized heterocyclic enamines
Bro?, B?etislav,R??i?ková, Zdeňka,?im?nek, Petr
, p. 118 - 141 (2016/10/22)
A simple methodology for [1,2-A]-fused tricyclic dihydroquinolines is established. The key ste of the methodology is an intramolecular Buchwald-Hartwig amination reaction of suitabl halogenated (both bromo and chloro) cyclic enaminoketones, enaminoesters and enaminonitrile with various ring size (from five-to seven-membered). Optimal reaction conditions (palladiu source, base, ligand) depend on the ring size of the starting enamine, giving 65-98% yield of th tricyclic product. A treatment of the products with perchloric acid gives respective quinoliniu perchlorates.
Ruthenium catalyzed synthesis of enaminones
Koduri, Naga Durgarao,Scott, Halee,Hileman, Bethany,Cox, Justin D.,Coffin, Michael,Glicksberg, Lindsay,Hussaini, Syed R.
, p. 440 - 443 (2012/03/10)
The Grubbs first-generation catalyst has been found to be an effective catalyst for the synthesis of enaminones by coupling thioamides with α-diazodicarbonyl compounds. The reaction is successful in converting primary, secondary, and tertiary thioamides into their corresponding enaminones. The reaction is also suitable for the synthesis of chiral enaminones.
Synthesis of acetyl-substituted heterocyclic enamines and their reaction with diethyl azodicarboxylate
Cheng,Zhao,Wang,Wang,Huang
, p. 1339 - 1351 (2007/10/02)
Acetyl-substituted heterocyclic enamines 4 were synthesized from lactim ethers 2 and acetylacetone through condensation and deacetylation reactions, and they, along with the ester-substituted heterocyclic enamines 6, reacted with diethyl azodicarboxylate to afford C-adducts 7 and 8 in excellent yields.
Studies on Pyrrolidones. Synthesis and N-Alkylation of &β-Enaminoesters Derived from Pyroglutamic Acid
Fasseur, Dominique,Rigo, Benoit,Leduc, Catherine,Cauliez, Pascal,Couturier, Daniel
, p. 1285 - 1291 (2007/10/02)
The condensation of iminoether 7, derived from pyroglutamic acid (4), with active methylene reagents such as Meldrum's acid or methyl cyanoacetate, lead to β-enaminoesters 2.Solid-liquid phase transfer N-alkylation of these compounds is described.
