70918-01-3

Basic information

• Product Name: Doxazosin hydrochloride
• Synonyms: DOXAZOSIN HYDROCHLORIDE;1-[(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine hydrochloride;1-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazineHCl;1-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazinehydrochloride
• CAS NO: 70918-01-3
• Molecular Formula: C₂₃H₂₅N₅O₅*ClH
• Molecular Weight: 487.94
• Product Categories: API
• Mol File: 70918-01-3.mol

Chemical Properties

• Boiling Point: 718 °C at 760 mmHg
• Flash Point: 388 °C
• Appearance: /
• Vapor Pressure: 1.83E-20mmHg at 25°C
• CAS DataBase Reference: Doxazosin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Doxazosin hydrochloride(70918-01-3)
• EPA Substance Registry System: Doxazosin hydrochloride(70918-01-3)

Safety Data

• Hazardous Substances Data: 70918-01-3(Hazardous Substances Data)

Usage

Uses

Used in Urology:
Doxazosin hydrochloride is used as a therapeutic agent for the treatment of benign prostatic hyperplasia (BPH). It works by blocking the α1-adrenoceptors in the prostate and bladder neck, leading to smooth muscle relaxation and improved urine flow. This helps to alleviate the symptoms of BPH, such as frequent urination, urgency, and difficulty in starting and maintaining a steady urine stream.
Used in Cardiology:
In the field of cardiology, doxazosin hydrochloride is used as an antihypertensive agent for the treatment of hypertension. It helps to lower blood pressure by blocking the α1-adrenoceptors in the blood vessels, causing vasodilation and reducing peripheral vascular resistance. This, in turn, leads to a decrease in blood pressure and a reduced workload on the heart, which can help prevent the development of cardiovascular complications.
Used in Research:
Doxazosin hydrochloride is also utilized in research settings as a pharmacological tool to study the role of α1-adrenoceptors in various physiological and pathological processes. It can be used to investigate the effects of α1-adrenoceptor activation or inhibition on blood pressure regulation, urinary function, and other related functions. Additionally, it can be employed to explore the potential therapeutic applications of α1-adrenoceptor antagonists in the treatment of other medical conditions, such as heart failure, erectile dysfunction, and certain neurodegenerative disorders.

InChI:InChI=1/C23H25N5O5.ClH/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H

Relevant articles and documents

Process for preparing amides

The present invention provides a process for preparing an amide, which comprises reacting an amine with an ester in a molten form in the absence of a solvent.