70921-62-9Relevant academic research and scientific papers
A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin
Kino, Kuniki,Kotanaka, Yoichi,Arai, Toshinobu,Yagasaki, Makoto
body text, p. 901 - 907 (2009/11/30)
L-Amino acid ligase catalyzes the formation of an α-peptide bond from unprotected L-amino acids in an ATP-dependent manner, and this enzyme is very useful in efficient peptide production. We performed enzyme purification to obtain a novel L-amino acid lig
Depigmenting activity of agouti signal protein and peptides thereof
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, (2008/06/13)
The invention is an agouti signaling protein and peptides as well as pharmaceutical compositions thereof and their use in methods of inhibiting melanin production by melanocytes. The agouti signaling protein and peptides thereof are useful in cosmetics and in clinical prevention and treatment of hyperpigmentary conditions. Methods for screening peptides for melanogenesis inhibiting activity are also provided.
Disulfide bridged cyclic peptides containing a cgridri sequence useful in control of hypertension
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, (2014/02/10)
Disulfide bridged cyclic peptides are described which are preferably 13 to 20 amino acid residues in length and which include the endocyclic sequence cys-gly-arg-ile-asp-arg-ile. Peptides of this class are selective for and show picomolar-range affinity for the non-guanyl cyclase-coupled atrial peptide receptor. Affinity for this receptor is associated with potentiation of the mean arterial pressure response to atrial peptide and these peptides are therefore useful in control of hypertension. Peptides of most interest are of the formula wherein X1 is the peptidic fragment ser-ser; wherein X2 is a peptidic fragment selected from gly-ser-gly-leu, gly-ala-gly-leu and gly-leu; wherein X3 is the peptidic fragment asn-ser-phe-arg; wherein m is zero or one, n is one and r is one; and wherein A represents an amino terminus or its pharmaceutically--acceptable salt, and B represents a carboxyl terminus or its pharmaceutically-acceptable ester, amide or salt.
Deblocking of peptides with proton donors
Kulikov, S. V.,Sokolova, N. Yu.,Samartsev, M. A.
, p. 1625 - 1631 (2007/10/02)
A series of model di- and tripeptides were synthesized, and they were deblocked with ammonium formate and cyclohexene in the presence of a palladium catalyst.It was shown that the deblocking of the peptides containing nitroarginine takes place readily and
