70935-14-7

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 7446-08-4 selenium(IV) oxide 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 22510-12-9 2-ethylamino-1-(3-hydroxy-phenyl)-ethanone 
• 872812-24-3 2-(3-hydroxyphenyl)quinoxaline 
• 52093-42-2 Neosynephrine ketone 
• 103656-55-9 3'-Hydroxyphenyl-isonitrosomethylketon 
• 70935-18-1 7-Amino-4-(3-hydroxy-phenyl)-1-methyl-1H-pyrimido[4,5-c]pyridazin-5-one 
• 80082-15-1 7-Amino-3-(3-hydroxy-phenyl)-1-methyl-1H-pyrimido[4,5-c]pyridazin-5-one 
• 925705-73-3 TG₁₀₀₁₁₀ 

Relevant academic research and scientific papers

Synthesis of α-keto aldehydes via selective Cu(i)-catalyzed oxidation of α-hydroxy ketones

An efficient approach to synthesize α-keto aldehydes was established through selective oxidation of α-hydroxy ketones catalyzed by Cu(i) using oxygen as oxidant. A wide array of α-keto aldehydes was prepared with isolated yields of up to 87%. The potential utilization of this reaction was evaluated by gram-scale reactions and synthetic applications.

Quinoxaline derivatives: Novel and selective butyrylcholinesterase inhibitors

Alzheimer's disease (AD) is a progressive brain disorder which occurs due to lower levels of acetylcholine (ACh) neurotransmitters, and results in a gradual decline in memory and other cognitive processes. Acetycholinesterase (AChE) and butyrylcholinesterase (BChE) are considered to be primary regulators of the ACh levels in the brain. Evidence shows that AChE activity decreases in AD, while activity of BChE does not change or even elevate in advanced AD, which suggests a key involvement of BChE in ACh hydrolysis during AD symptoms. Therefore, inhibiting the activity of BChE may be an effective way to control AD associated disorders. In this regard, a series of quinoxaline derivatives 1-17 was synthesized and biologically evaluated against cholinesterases (AChE and BChE) and as well as against achymotrypsin and urease. The compounds 1-17 were found to be selective inhibitors for BChE, as no activity was found against other enzymes. Among the series, compounds 6 (IC50 = 7.7 ± 1.0μM) and 7 (IC50 = 9.7 ± 0.9 μM) were found to be the most active inhibitors against BChE. Their IC50 values are comparable to the standard, galantamine (IC50 = 6.6 ± 0.38 μM). Their considerable BChE inhibitory activity makes them selective candidates for the development of BChE inhibitors. Structure-activity relationship (SAR) of this new class of selective BChE inhibitors has been discussed.

Kinetics and mechanism of oxidation of o-, m- and p-hydroxy-acetophenones by hexacyanoferrate(III) in alkaline medium

Oxidation of o-, p- and m-hydroxyacetophenones by hexacyanoferrate(III) in alkaline medium is first order each in and .Added KCl and increase in increase the rate.Activation parameters have been calculated and

Structure-activity Relationship of Herbicidal 2,3-Dicyano-5-Substituted Pyrazines

Sixty six 2,3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity.The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.