709638-30-2

Basic information

• Product Name: [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester
• Synonyms: [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester
• CAS NO: 709638-30-2
• Molecular Weight: 370.408
• Mol File: 709638-30-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester(709638-30-2)
• EPA Substance Registry System: [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester(709638-30-2)

Safety Data

• Hazardous Substances Data: 709638-30-2(Hazardous Substances Data)

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 7065-92-1 2-chloro-3-phenylquinoxaline 

Downstream Products

• 709638-50-6 (S)-2-{2-[4-(3-Phenyl-quinoxalin-2-yloxy)-phenyl]-acetylamino}-pentanedioic acid diethyl ester 
• 709638-40-4 [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid 

Relevant articles and documents

Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates analogs of methotrexate: Synthesis and evaluation of in vitro anticancer activity

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 M concentrations. Interesting selectivities were also recorded between 10-8 and 10-6 M for the compounds 9 and 13.