709666-24-0

Basic information

• Product Name: 4-Pyridinecarboxylicacid,3-amino-5-methoxy-,ethylester(9CI)
• Synonyms: 4-Pyridinecarboxylicacid,3-amino-5-methoxy-,ethylester(9CI)
• CAS NO: 709666-24-0
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.2
• Product Categories: AMINOACID
• Mol File: 709666-24-0.mol

Chemical Properties

• Boiling Point: 355.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• PKA: 3.97±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridinecarboxylicacid,3-amino-5-methoxy-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylicacid,3-amino-5-methoxy-,ethylester(9CI)(709666-24-0)
• EPA Substance Registry System: 4-Pyridinecarboxylicacid,3-amino-5-methoxy-,ethylester(9CI)(709666-24-0)

Safety Data

• Hazardous Substances Data: 709666-24-0(Hazardous Substances Data)

Upstream product

• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 625-92-3 3,5-dibromopyridine 
• 709666-23-9 ethyl 3-[(tert-butoxycarbonyl)amino]-5-methoxyisonicotinate 

Downstream Products

• 1202013-46-4 3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione 
• 1202013-44-2 3-(3-chloro-4-fluorobenzyl)-5-methoxy-8-[(methyl{4-[(methylsulfonyl)oxy]butyl}amino)carbonyl]-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-6-yl methanesulfonate 
• 1202013-42-0 3-(3-chloro-4-fluorobenzyl)-6-hydroxy-N-(4-hydroxybutyl)-5-methoxy-N-methyl-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxamide 
• 1202013-40-8 3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid 
• 1202013-38-4 methyl 6-(acetyloxy)-3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-carboxylate 
• 1202013-36-2 methyl 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-carboxylate-7-oxide 
• 1202013-34-0 methyl 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-carboxylate 
• 1202013-32-8 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl trifluoromethanesulfonate 
• 1202013-30-6 3-(3-chloro-4-fluorobenzyl)-8-hydroxy-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one 
• 1202013-28-2 3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-yl acetate 
• 1202013-26-0 3-(3-chloro-4-fluorobenzyl)-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one-7-oxide 
• 1202013-24-8 3-(3-chloro-4-fluorobenzyl)-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one 
• 1202013-20-4 3-(3-chloro-4-fluorobenzyl)-5-hydroxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione 

Relevant articles and documents

HIV INTEGRASE INHIBITORS

Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein G, T, R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A and R6B are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Synthesis of a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one derivative via directed ortho-metallation of a pyridine analogue

The synthetic strategy towards a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one is described, utilizing palladium catalyzed amination of a bromopyridine, and subsequent directed ortho-metallation/carboxylation as the key steps.