709676-56-2

Usage

Uses

Used in Biochemical Research:
N-(4-chloro-3-trifluoromethyl-phenyl)-2-n-propoxybenzamide is used as a modulator of enzymes histone acetyltransferases (HATs) for studying the role of these enzymes in various biological processes. HATs are responsible for the acetylation of histone proteins, which plays a crucial role in regulating gene expression and chromatin structure.
Used in Drug Development:
N-(4-chloro-3-trifluoromethyl-phenyl)-2-n-propoxybenzamide is used as a potential therapeutic agent in the development of drugs targeting chromatin transcription. By modulating the activity of histone acetyltransferases, N-(4-chloro-3-trifluoromethyl-phenyl)-2-n-propoxybenzamide may have implications in the treatment of diseases associated with abnormal gene expression and chromatin remodeling, such as cancer and other genetic disorders.
Used in Chemical Synthesis:
N-(4-chloro-3-trifluoromethyl-phenyl)-2-n-propoxybenzamide is used in the preparation of benzamide compounds, which serve as important intermediates in the synthesis of various pharmaceuticals and agrochemicals. The unique structure of N-(4-chloro-3-trifluoromethyl-phenyl)-2-n-propoxybenzamide allows for further chemical modifications and the development of novel compounds with improved properties and applications.

Upstream product

• 54090-36-7 2-propoxybenzoyl chloride 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 369-74-4 N-(4'-chloro-3'-(trifluoromethyl)phenyl)-2-hydroxybenzamide 
• 107-08-4 1-iodo-propane 
• 69-72-7 salicylic acid 
• 92156-43-9 2-propoxybenzoic acid propyl ester 

Relevant academic research and scientific papers

HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF

Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

A NANOSPHERE - HISTONE ACETYLTRANSFERASE (HAT) ACTIVATOR COMPOSITION, PROCESS AND METHODS THEREOF

The present disclosure is in relation to a composition comprising nanosphere and histone acetyltransferase (HAT) activator. The disclosed nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide [COMPOUND 1]. The said N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present disclosure further relates to a process for obtaining a composition comprising carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The said composition thus provides for managing pathological conditions to a subject in need thereof, such as aging- related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit.

HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

Modulators (inhibitors/ activators) of histone acetyltransferases

Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma.