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Acetamide, N-(hydroxymethyl)-N-methyl-, also known as N-Methyl-N-(hydroxymethyl)acetamide or N-Methyl-N-hydroxymethylacetamide, is an organic compound with the chemical formula C4H9NO2. It is a colorless, crystalline solid that is soluble in water and slightly soluble in organic solvents. Acetamide, N-(hydroxymethyl)-N-methyl- is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products. It is also known for its potential applications in the production of polymers and as a reagent in organic synthesis. The compound is synthesized through the reaction of acetamide with formaldehyde in the presence of a base, such as sodium hydroxide. Due to its reactivity and potential applications, it is an important compound in the field of organic chemistry.

7099-77-6

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7099-77-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7099-77-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,9 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7099-77:
(6*7)+(5*0)+(4*9)+(3*9)+(2*7)+(1*7)=126
126 % 10 = 6
So 7099-77-6 is a valid CAS Registry Number.

7099-77-6Downstream Products

7099-77-6Relevant academic research and scientific papers

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: Chemical hydrolysis and anti-bacterial activity

Moreira, Rui,Calheiros, Teresa,Cabrita, Jose,Mendes, Eduarda,Pimentel, Madalena,Iley, Jim

, p. 70 - 75 (2007/10/03)

Purpose. O-(N-alkylamido)methyl esters of penicillin G were studied as a new class of prodrugs. Methods. Their hydrolysis in aqueous buffers containing 20% (v/v) of acetonitrile was investigated by HPLC. Results. A U-shaped pH-rate profile was seen with a pH-independent process extending from pH ca. 2 to pH ca. 10. This pathway is characterised by kinetic data that are consistent with a unimolecular mechanism involving rate-limiting iminium ion formation and penicillinoate expulsion. Penicillin G and the corresponding amide are the ultimate products detected and isolated, indicating that p-lactam ring opening is much slower than ester hydrolysis. The O-(N-alkylamido)methyl esters of penicillin G displayed similar in vitro antibacterial activity to penicillin G itself. Conclusions. Compared to the penicillin G derivatives, the much higher stability of the O-(N-methylbenzamido)methyl benzoate, acetate and valproate esters (which gave rise to a Bronsted β(1g) value of ca. -1) suggests that tertiary N-acyloxymethylamides may be useful prodrugs for carboxylic acid drugs with pK(a) > 4.

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