71001-57-5Relevant academic research and scientific papers
Preparation of 5-functionalised pyridine derivatives using a Br/Mg exchange reaction: application to the synthesis of an iron-chelator prodrug
Zhou, Dongheng,Tian, Yufei,Ma, Yongmin
, p. 627 - 630 (2017)
A novel preparation of 5-functionalised pyridine derivatives is reported from 5-bromo-4-tosyloxypyridines via a Br/Mg exchange procedure with i-PrMgClLiCl, followed by addition of an electrophile. The reaction was carried out under mild conditions and gave good to high yields. The resulting 5-functionalised pyridine derivatives enrich the library of pyridinone-type iron-chelator prodrugs.
The synthesis of 5-functional 3-hydroxypyridin-4-ones and their impact on the chelating properties of the ligands
Chen, Yu-Lin,Chen, Jing,Ma, Yongmin,Hider, Robert C.
, p. 515 - 517 (2015/05/27)
The presence of the 5-functional group on 3-hydroxypyridin-4-ones (HPOs) can significantly change their chelating properties because the 5-position is adjacent to one of the chelating moieties. A 5-methoxy-substituted HPO has been successfully synthesized using a 5-bromo analogue with NaOMe in the presence of a copper(I) catalyst. The atomic charges and stability constants of the HPOs with either electron-donating or election-withdrawing groups on the 5-position were compared. The result showed that the 5-substituted HPOs possess lower stability constants, compared to those of the 5-unsubstituted analogue (deferiprone).
Synthesis of 5-benzyloxy-1,4-dihydro-6-methyl-4-oxopyridine-3-carbaldehyde by aerobic oxidation of the 5-dimethylaminomethyl analogue: optimisation of the reaction conditions
Ma, Yong Min,Hider, Robert C
body text, p. 1415 - 1418 (2010/05/03)
A successful introduction of the formyl group at position 5 of 3-hydroxypyridin-4-one was achieved by aerobic oxidation, catalysed by NHS/Co(II). To obtain a practical yield, the reaction conditions were optimised.
HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE
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Page/Page column 119-120, (2008/06/13)
Bi-or tricyclic compounds of formula (I) wherein R1, R4 and R5 are as herein defined, A represents a single or double bond and two R2, R2’, R3 and R3’ can be joined to form a condensed or spiro ring. These compounds and their pharmaceutical acceptable salt are used in combinations or pharmaceutical compositions and are useful in methods for preventing or treatin human immunodeficiency virus (HIV) infection or in methods for preventing, delaying or treating acquired immunodeficiency syndrome (AIDS).
