71005-75-9

Basic information

• Product Name: 4-ethyloxazol-2(3H)-one
• Synonyms: 4-ethyloxazol-2(3H)-one
• CAS NO: 71005-75-9
• Molecular Weight: 113.116
• Mol File: 71005-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-ethyloxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyloxazol-2(3H)-one(71005-75-9)
• EPA Substance Registry System: 4-ethyloxazol-2(3H)-one(71005-75-9)

Safety Data

• Hazardous Substances Data: 71005-75-9(Hazardous Substances Data)

Upstream product

• 59463-53-5 cyanomethyl ethyl carbonate 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 13896-06-5 (S)-(-)-4-ethyl-2-oxazolidinone 
• 71005-81-7 3-(2-chloro-benzoyl)-4-ethyl-3H-oxazol-2-one 
• 71005-78-2 4-ethyl-3-(4-methoxy-benzoyl)-3H-oxazol-2-one 

Relevant articles and documents

Titanium-mediated addition of grignard reagents to acyl cyanohydrins: Aminocyclopropane versus 1,4-diketone formation

The 1,2-dianion reactivity of the reagent generated from EtMgBr and titanium isopropoxide was illustrated when N-acyl cyanohydrins were used as substrates (>20 examples), giving both aminocyclopropane derivatives and 1,4-dicarbonyl compounds. When the reaction was performed in diethyl ether, 5-hydroxy-1,4-diketones were the main product. Under specific conditions (use of tetrahydrofuran and a bulky carboxylic moiety), the cyclopropane derivatives were obtained in good yields. The observed dichotomy may be explained by a ring-opening of the five-membered titanacycle intermediate followed by a nonselective acyl addition. The 1,2-dianion reactivity of the reagent generated from EtMgBr and Ti(OiPr)4 was illustrated when N-acyl cyanohydrins were used as substrates (>20 examples). When the reaction was performed in diethyl ether, 1,4-diketones were mainly isolated. Under certain conditions, cyclopropane derivatives were also obtained in good yields. A mechanism rationalizing this dichotomy is presented. Copyright