71018-12-7Relevant academic research and scientific papers
Total synthesis of the antifungal agent echinocandinc
Messik, Frauke,Oberthür, Markus
, p. 5871 - 5875 (2013/07/05)
Reliably stable: A dipeptide building block with fully elaborated N-acyl hemiaminal proved to be a versatile precursor for echinocandinC, a prototypical member of the echinocandin group of antimycotic drugs. This first total synthesis of an N-acyl hemiaminal-containing echinocandin is concise and highly convergent, thereby making additional derivatives easily accessible. PG=protecting group. Copyright
Reduction Studies of Antifungal Echinocandin Lipopeptides. One Step Conversion of Echinocandin B to Echinocandin C.
Balkovec, James M.,Black, Regina M.
, p. 4529 - 4532 (2007/10/02)
Sodium cyanoborohydride in trifluoroacetic acid selectively reduced the C5-orn and C4-htyr carbinols to methylene groups in echinocandin lipopeptides.The selective reduction of either hydroxyl is also described.The first conversion of echinocandin C was a
